亚洲 丝袜 美腿 制服 变态_国产SUV精品一区二区五_国产在线一区二区香蕉 在线_精品亚洲国产成人av网站_国产乱子伦视频大全亚瑟影院_国产亚洲欧洲综合5388

您好,歡迎光臨上海雅吉生物商城!
工作時間:9:00-18:00
全國服務熱線:021-34661276

Toll樣受體2抗體

規(guī)格
價格庫存
訂購熱線:021-34661276
我要詢價
  • 商品詳情
  • 售后服務
  • 相關文獻

 

中文名稱 Toll樣受體2抗體
別    名 Toll-like receptor 2; Toll like receptor 2; Toll like receptor 2 precursor; Toll-like receptor 2; TLR 2; TLR-2; Toll/interleukin-1 receptor-like protein 4; CD282 antigen; CD282; TIL 4; TIL4; TLR2_HUMAN; Toll/interleukin 1 receptor like 4; Toll/interleukin 1 receptor like protein 4; Toll/interleukin receptor like protein 4.  

 

 

研究領域 腫瘤  免疫學  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Sheep, )
產品應用 WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 (石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TLR2:701-784/784 
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
產品介紹 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008].

Function:
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Subunit:
Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

Post-translational modifications:
Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.

Similarity:
Belongs to the Toll-like receptor family.
Contains 14 LRR (leucine-rich) repeats.
Contains 1 TIR domain.

SWISS:
O60603

Gene ID:
7097

Database links:

Entrez Gene: 7097 Human

Entrez Gene: 24088 Mouse

Entrez Gene: 310553 Rat

Omim: 603028 Human

SwissProt: O60603 Human

SwissProt: Q9QUN7 Mouse

Unigene: 519033 Human

Unigene: 87596 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Toll樣受體2(TLR2)通過激活天然免疫,參與特異性免疫應答的啟動,Toll樣受體2(TLR2)作為一種重要跨膜信號轉導受體參與了內毒素誘發(fā)炎癥反應的病理過程,對其調控機制的研究日益受到關注。
產品圖片 Sample:
Spleen(Mouse) Lysate at 40 ug
Thymus (MouseLysate at 20 ug
Primary: Anti-TLR2 (bs-1019R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 84 kD
Observed band size: 110 kD
Sample:
Lane 1: Spleen (Rat) Lysate at 40 ug
Lane 2: Bronchus (Rat) Lysate at 40 ug
Lane 3: Lung (Rat) Lysate at 40 ug
Primary: Anti-TLR2 (bs-1019R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 100 kD
Observed band size: 98 kD
Sample:
Cerebrum (Rat) Lysate at 40 ug
Primary: Anti-TLR2 (bs-1019R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 84 kD
Observed band size: 95 kD
Sample:
Raw264.7 (Mouse) Lysate at 30 ug
Primary: Anti-TLR2 (bs-1019R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 84 kD
Observed band size: 104kD
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TLR2) Polyclonal Antibody, Unconjugated (bs-1019R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.Tissue/cell: rat ovary tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-TLR2 Polyclonal Antibody, Unconjugated(bs-1019R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

我要詢價
*聯系方式:
(可以是QQ、MSN、電子郵箱、電話等,您的聯系方式不會被公開)
*內容:


微信客服
掃一掃立即咨詢


微信客服
掃一掃立即咨詢

銷售電話:

021-34661275

021-34661276

15301693058