Product Details
- Verified Reactivity
- Human
- Reported Reactivity
- Cynomolgus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Primary human Langerhans cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported application (for the relevant formats) includes: blocking the binding of HIV-1 to Langerhans cells1.
- Application References
(PubMed link indicates BioLegend citation) -
- Witte LD, et al. 2007. Nat. Med. 13:367. (Block)
- Product Citations
-
- RRID
- AB_10900993 (BioLegend Cat. No. 352203) AB_10897451 (BioLegend Cat. No. 352204)
Antigen Details
- Structure
- 40 kD glycoprotein
- Distribution
-
Langerhans cells, dermal CD103-positive dendritic cells, and splenic CD8-positive dendritic cells
- Function
- Binding and processing antigen; capturing, internalizing and degrading HIV
- Ligand/Receptor
- Antigen containing mannose, N-acetyl glucosamine, and fucose
- Cell Type
- Dendritic cells, Langerhans cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
1. Valladeau J, et al. 2000. Immunity 12:71.
2. Mc Dermott R, et al. 2002. Mol. Biol. Cell. 13:317.
3. Mizumoto N, et al. 2004. J. Clin. Invest. 113:701.
4. Witte LD, et al. 2007. Nat. Med. 13:367. - Gene ID
- 50489 View all products for this Gene ID
- UniProt
- View information about CD207 on UniProt.org
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