Product Details
- Verified Reactivity
- Mouse, Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Full length recombinant human Rad23B protein.
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, 0.09% sodium azide.
- Preparation
- Protein G affinity purified.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
KO/KD-WB - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Rad23B has two isoforms, and the predicted Mws are 43kD and 35kD respectively. For 43kD isoform, the observed Mw is 53kD.
- RRID
- AB_2561795 (BioLegend Cat. No. 654201)
Antigen Details
- Structure
- 409 amino acids, predicted molecular weight of 43 kD
- Distribution
-
Nucleus, cytoplasm (the intracellular distribution is cell cycle dependent)
- Function
- Modulation of proteasomal degradation; involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex
- Interaction
- Component of the XPC complex composed of XPC, RAD23B and CETN2; interacts with NGLY1, PSMC1, ATXN3, PSMD4, PSMC5, and AMFR
- Cell Type
- B cells
- Biology Area
- Cell Biology, Immunology, Ubiquitin/Protein Degradation
- Antigen References
-
1. Sugasawa K, et al. 1997. Mol. Cell Biol. 17:6924.
2. Thoma BS and Vasquez KM. 2003. Mol. Carcinog. 38:1.
3. Reina CP, et al. 2010. Hum. Mol. Genet. 19:235.
4. Farmer LM, et al. 2010. Plant Cell 22:124.
5. Khan O, et al. 2010. Proc. Natl. Acad. Sci. USA 107:6532.
6. Kamiya Y, et al. 2012. FEBS Lett. 586:1141. - Gene ID
- 5887 View all products for this Gene ID
- UniProt
- View information about Rad23B on UniProt.org
