| 產(chǎn)品編號 | bs-43562P |
| 英文名稱 | Recombinant human TNFRSF14 protein, C-His (HEK293) |
| 中文名稱 | 重組人TNFRSF14蛋白 |
| 別 名 | HVEM; Tumor necrosis factor receptor superfamily member 14; HveA1; Tumor necrosis factor receptor-like 2; TR21; CD270; Herpesvirus entry mediator A; TNR14_HUMAN. Similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen); CD258; CD258 antigen; CD40 like protein precursor; Herpesvirus entry mediator; Herpesvirus entry mediator ligand; HVEA; HVEM L; HVEML; LIGHT; LIGHTR; TNFSF 14; TR2; UNQ329/PRO509 |
| 理論分子量 | 18.4kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >0.72mg/ml |
| 物 種 | Human |
| 序 列 | 39-202/283 |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達系統(tǒng) | HEK293 cell |
| 活性 | Not tested |
| 標簽 | C-His |
| 緩 沖 液 | PBS (pH=7.4) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. SWISS: Q92956 Gene ID: 8764 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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