| 產品編號 | bs-42131P |
| 英文名稱 | Recombinant human FMN1 protein, His |
| 中文名稱 | 重組人肢體畸形相關蛋白FMN1 |
| 別 名 | FMN; Formin 1; Formin1; Formin-1; LD; Limb deformity protein homolog; FMN1_HUMAN. |
| 理論分子量 | 41.4kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >1mg/ml |
| 物 種 | Human |
| 序 列 | 1-354/1419 |
| 純 度 | >90% as determined by SDS-PAGE |
| 內毒素 | Not analyzed |
| 活性 | Not tested |
| 標簽 | N-His |
| 緩 沖 液 | 20mM Tris (pH=8.0) with 2M Urea |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產品介紹 | The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. In mice, the limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of proteins known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing Actin filament assembly. Formins co-localize with the actin cytoskeleton and can translocate into the cell cytosol and into the nucleus in an HGF-dependent manner. Vertebrate nuclear formins can control polarizing activity in limb buds through establishment of a Sonic hedgehog/FGF-4 feedback loop. Deficiency mutations at the mammalian ld locus lead to profound developmental defects in limb and kidney formation. The human Formin 1 and 2 genes map to chromosome 15q13.3 and 1q43, respectively. SWISS: Q68DA7 Gene ID: 342184 |
| 產品圖片 |  The purity of the protein is greater than 83% as determined by reducing SDS-PAGE. |
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