| 產(chǎn)品編號(hào) | bs-43032P |
| 英文名稱 | Recombinant mouse CD19 protein, C-His (HEK293) |
| 中文名稱 | 重組小鼠CD19蛋白 |
| 別 名 | CD19_MOUSE; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19; B-lymphocyte surface antigen B4; Leu 12; Leu12; |
| 理論分子量 | 33.3kDa |
| 性 狀 | Lyophilized or Liquid |
| 物 種 | Human |
| 序 列 | 19-287/547 |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | HEK293 cell |
| 活性 | Not tested |
| 標(biāo)簽 | C-His |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020] SWISS: P25918 Gene ID: 12478 CD19是一種質(zhì)膜蛋白質(zhì)，參與信號(hào)傳導(dǎo)作用。表達(dá)與前B細(xì)胞和成熟的B細(xì)胞膜表面，與B細(xì)胞的活化調(diào)節(jié)和發(fā)育調(diào)節(jié)相關(guān)，在T細(xì)胞和正常粒細(xì)胞上無(wú)表達(dá)。此抗體可以特異性識(shí)別CD19，主要用于標(biāo)記正常B細(xì)胞及腫瘤性B細(xì)胞。 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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