| 產(chǎn)品編號 | bs-42067P |
| 英文名稱 | Recombinant EV71 VP1 protein, N-His |
| 中文名稱 | 重組腸道病毒71型/手足口病病毒VP1蛋白 |
| 別 名 | EV71; Enterovirus 71; EV71 polyprotein VP1; Enterovirus 71 polyprotein VP1; EV71 VP1; EV71-VP1. |
| 理論分子量 | 36.1kDa |
| 檢測分子量 | 76 kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >0.5mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | E.coli |
| 標(biāo)簽 | N-His |
| 緩 沖 液 | 20mM Tris-Hcl (pH=8.0) with 8M Urea |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Enteroviruses, such as enterovirus 71, are classified to be in the picornavirus family, pico [small] + RNA [ribonucleic acid] + virus. Picornaviruses are among the smallest and simplest ribonucleic acid containing viruses known (1). The RNA for many enteroviruses have now been cloned and complete genomic sequences have been obtained. The RNA from all sequenced enteroviruses are similar in length, about 7400 nucleotides, and have identical organization (1). The human alimentary tract is the predominant site of enterovirus replication and these viruses were first isolated from enteric specimens. These viruses are the cause of paralytic poliomyelitis, aseptic meningitis-encephalitis, myocarditis, pleurodynia, hand-foot-and-mouth disease, conjunctivitis, and numerous other syndromes associated with extra-intestinal target organs. There are 67 numbered types of enteroviruses in the enterovirus family (1): three polioviruses, twenty-three coxsackieviruses A, six coxsackieviruses B, thirty-one echoviruses, and four other enteroviruses. SWISS: Q66478 腸道病毒71型(Human enterovirus 71)簡稱EV71。腸病毒在病毒學(xué)上的分類是屬于微小病毒科(picornaviridae)中的腸病毒群(enterovirus)。 EV 71為目前腸病毒群中最晚發(fā)現(xiàn)的病毒，其感染性強(qiáng)且致病率高，尤其是神經(jīng)系統(tǒng)方面的并發(fā)癥。EV71主要引起手足口病，還可引起無菌性腦膜炎、腦干腦炎和脊髓灰質(zhì)炎樣的麻痹等多種神經(jīng)系統(tǒng)疾病。手足口病和中樞神經(jīng)系統(tǒng)感染是EV71感染而引起的兩大常見臨床癥狀。 腸道病毒71型病毒從咽部或腸道侵入，在局部黏膜或淋巴組織中繁殖，并由局部排出，此時(shí)可引起局部癥狀。繼而病毒又侵入局部淋巴結(jié)，并由此進(jìn)入血液循環(huán)導(dǎo)致第一次病毒血癥。病毒經(jīng)血循環(huán)侵入網(wǎng)狀內(nèi)皮組織、深層淋巴結(jié)、肝、脾、骨髓等處大量繁殖并由此進(jìn)入血液循環(huán)，引起第二次病毒血癥。病毒可隨血流進(jìn)入全身各器官，如中樞神經(jīng)系統(tǒng)、皮膚黏膜、心臟等處，進(jìn)一步繁殖并引起病變。 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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