| 產(chǎn)品編號 | bs-42286P |
| 英文名稱 | Recombinant human NFKB p65 protein, N-GST |
| 中文名稱 | 重組人細(xì)胞核因子/k基因結(jié)合核因子蛋白 |
| 別 名 | kB P65; NF-kB p65; NFKBp65; NF-κBp65; NF-kBp65; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; Nuclear Factor NF Kappa B p65 Subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells; p65; p65 NF kappaB; p65 NFkB; RELA; Transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; TF65_HUMAN. |
| 理論分子量 | 62.5kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >0.5mg/ml |
| 物 種 | Human |
| 序 列 | 1-306/551 |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | E.coli |
| 標(biāo)簽 | N-GST |
| 緩 沖 液 | 50mM Tris-Hcl (pH=8.0) with 10mM GSH |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. SWISS: Q04206 Gene ID: 5970 轉(zhuǎn)錄調(diào)節(jié)因子（Transcriptin Regulators） NF-κBp65是一種重要的轉(zhuǎn)錄因子，NF-kBp65可激活參與炎癥、細(xì)胞增殖、細(xì)胞凋亡等基因的調(diào)節(jié)，影響著細(xì)胞的凋亡，同時影響著腫瘤細(xì)胞對細(xì)胞毒性藥物及離子輻射的敏感性。ras基因誘導(dǎo)的致癌突變作用需NFkB的活化，提示NFkB在致癌發(fā)生方面可能起一定作用；另有文獻(xiàn)報道，在乳腺癌、非小細(xì)胞性肺癌、甲狀腺癌、T或B淋巴細(xì)胞白血病及病毒誘變導(dǎo)致的腫瘤等人類腫瘤中，NFkB活化或表達(dá)。 經(jīng)研究認(rèn)為：NFKBp65蛋白在靜息狀態(tài)下以結(jié)合態(tài)的方式存在于胞漿中，當(dāng)NFKBp65蛋白被激活后解離進(jìn)入細(xì)胞核。(NF-κB與其抑制蛋白IκB家族成員結(jié)合，以無活性的復(fù)合物形式存在于胞漿中，當(dāng)細(xì)胞受到各種刺激后，NF- κB與IκB 解離，從而進(jìn)入細(xì)胞核，與相應(yīng)的靶序列結(jié)合，調(diào)節(jié)基因的表達(dá)) |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 85% as determined by reducing SDS-PAGE. |
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