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人白介素6單克隆抗體

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產品編號V0402
英文名稱human IL-6
中文名稱人白介素6單克隆抗體
別    名Interleukin BSF 2; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; Cytotoxic T cell differentiation factor; Hepatocyte stimulating factor; HGF; HPGF; HSF; Hybridoma growth factor; Hybridoma plasmacytoma growth factor; IFNB2; IL 6; IL6 protein; Interferon beta 2; Interleukin 6 (interferon beta 2); Interleukin 6; Interleukin-6; Interleukin6; IL6_HUMAN.  
克 隆 號5C7K
理論分子量23kDa
細胞定位分泌型蛋白 
性    狀Liquid
濃    度≥1mg/ml
緩 沖 液0.01M PBS(pH7.4) with 0.1% Proclin300.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions.

Function:
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

Subcellular Location:
Secreted.

Post-translational modifications:
N- and O-glycosylated.

DISEASE:
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

Similarity:
Belongs to the IL-6 superfamily.

SWISS:
P05231

Gene ID:
3569

Database links:

Entrez Gene: 3569 Human

Entrez Gene: 16193 Mouse

Entrez Gene: 24498 Rat

Omim: 147620 Human

SwissProt: P05231 Human

SwissProt: P08505 Mouse

SwissProt: P20607 Rat

Unigene: 654458 Human

Unigene: 1019 Mouse

Unigene: 9873 Rat



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